Weeds for a long time coexist with cultivated plants in agrophytocenoses and can be considered as indicators of biodiversity. From the phytocenotic viewpoint, the existence and persistence of weeds are quite natural, but for economic reasons weeds are negative factors because of their competition with cultivated plants (crops) for water, nutrients, and living space. The strategic task of crop protection is the control of weeds at the economic threshold of harm. Under modern conditions, the use of integrated crop protection technologies, which involve combining and harmonizing crop rotation schemes, agrotechnics and chemical protection means, becomes of particular importance. The article discusses the issues related to the need for integrated application of several active ingredients of herbicides, which complement each other by their spectrum of action, improve the effectiveness of weed control, and prevent the emergence of resistance of weeds to specific herbicides. The basic regularities of the changes of selective phytotoxicity in complexes of herbicides with different mechanisms of their action, which were established in the course of researches, became the basis for development of various effective herbicidal complexes and mixtures for protection of various crops. According to the current strategy, the application of integrated crop protection systems should ensure the maintenance or reduction of potential infestation with weeds during rotation of crops. At that, the weed species composition in agrophytocenoses should not undergo abrupt changes, except for a significant reduction of the potential contamination by especially harmful weedy species.
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